English: The cyclotide precursor is comprised a hydrophobic signal peptide that targets the precursor to the Endoplasmic Reticulum (ER), an N-terminal propeptide that then targets it to the vacuole, a cyclotide domain and a final C-terminal propeptide necessary for cyclisation.
The cyclotide domain folds in the ER, after which it is trafficked to the vacuole and the cyclotide domain is cyclised by an asperginyl endopeptidase. (PDB: 1WN8, 1NB1)
láti pín pẹ̀lú ẹlòmíràn – láti ṣàwòkọ, pínkiri àti ṣàgbéká iṣẹ́ náà
láti túndàpọ̀ – láti mulò mọ́ iṣẹ́ míràn
Lábẹ́ àwọn àdéhùn wọ̀nyí:
ìdárúkọ – Ẹ gbọdọ̀ ṣe ọ̀wọ̀ tó yẹ, pèsè ìjápọ̀ sí ìwé-àṣe, kí ẹ sì sọ bóyá ìyípadà wáyé. Ẹ le ṣe èyí lórísi ọ̀nà tó bojúmu, sùgbọ́n tí kò ní dà bii pé oníìwé-àṣe fọwọ́ sí yín tàbí lílò yín.
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