Acyloin condensation

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Acyloin condensation jẹ́ ìyọkúrò àsopọ̀ àwọn carboxylic ester pẹ̀lú lílò metalic sodium lati ṣèdá α-hydroxyketone, tí wọ́n tún mọ̀ sí.[1][2][3]

The acyloin condensation

Àdàpọ̀ ṣisẹ́ yìí jẹ́ èyí tó laṣeyọrí jùlọ nígbà tí R jẹ́ aliphatic àti inert. Àdàpọ̀ ṣisẹ́ yìí ń di ṣíṣe ní aprotic solvents pẹ̀lú  boiling point, tó pọ̀ bíi  benzene àti toluene. The use of protic solvents results in the Bouveault-Blanc reduction of the separate esters rather than condensation. Depending on ring size and steric properties, but independent from high dilution, the acyloin condensation of diesters favours intramolecular cyclisation over intermolecular polymerisation.

Àwọn ìtọ́kasí[àtúnṣe | àtúnṣe àmìọ̀rọ̀]

  1. Bouveault, L.; R. Loquin (1905).
  2. Finley, K. T. (1964).
  3. Bloomfield, J. J.; Owsley, D. C.; Nelke, J. M. Org.