| Name | Nationality | Position | Apps | Club(s) | First | Last |
| Barry, GarethGareth Barry | England | MF | 653 | Aston Villa, Manchester City, Everton, West Bromwich Albion | 1998 | 2018 |
| Giggs, RyanRyan Giggs | Wales | MF | 632 | Manchester United | 1992 | 2014 |
| Frank Lampard | England | MF | 609 | West Ham United, Chelsea, Manchester City | 1996 | 2015 |
| James, DavidDavid James | England | GK | 572 | Liverpool, Aston Villa, West Ham United, Manchester City, Portsmouth | 1992 | 2010 |
| Speed, GaryGary Speed | Wales | MF | 535 | Leeds United, Everton, Newcastle United, Bolton Wanderers | 1992 | 2007 |
| Milner, JamesJames Milner | England | MF | 532 | Leeds United, Newcastle United, Aston Villa, Manchester City, Liverpool | 2002 | 2020 |
| Heskey, EmileEmile Heskey | England | FW | 516 | Leicester City, Liverpool, Birmingham City, Wigan Athletic, Aston Villa | 1995 | 2012 |
| Schwarzer, MarkMark Schwarzer | Australia | GK | 514 | Middlesbrough, Fulham, Chelsea, Leicester City | 1996 | 2016 |
| Carragher, JamieJamie Carragher | England | DF | 508 | Liverpool | 1997 | 2013 |
| Neville, PhilipPhilip Neville | England | MF | 505 | Manchester United, Everton | 1995 | 2013 |
| Ferdinand, RioRio Ferdinand | England | DF | 504 | West Ham United, Leeds United, Manchester United, Queens Park Rangers | 1996 | 2015 |
| Steven Gerrard | England | MF | 504 | Liverpool | 1998 | 2015 |
| Campbell, SolSol Campbell | England | DF | 503 | Tottenham Hotspur, Arsenal, Portsmouth, Newcastle United | 1992 | 2011 |
| Scholes, PaulPaul Scholes | England | MF | 499 | Manchester United | 1994 | 2013 |
| Defoe, JermainJermain Defoe | England | FW | 496 | West Ham United, Tottenham Hotspur, Portsmouth, Sunderland, Bournemouth | 2001 | 2018 |
| Terry, JohnJohn Terry | England | DF | 492 | Chelsea | 1998 | 2017 |
| Rooney, WayneWayne Rooney | England | FW | 491 | Everton, Manchester United | 2002 | 2018 |
| Carrick, MichaelMichael Carrick | England | MF | 481 | West Ham United, Tottenham Hotspur, Manchester United | 1999 | 2018 |
| Distin, SylvainSylvain Distin | France | DF | 469 | Newcastle United, Manchester City, Portsmouth, Everton, Bournemouth | 2001 | 2016 |
| Crouch, PeterPeter Crouch | England | FW | 468 | Aston Villa, Southampton, Liverpool, Portsmouth, Tottenham Hotspur, Stoke City, Burnley | 2002 | 2019 |
| Hughes, AaronAaron Hughes | Àdàkọ:Country data Northern Ireland Northern Ireland | DF | 455 | Newcastle United, Aston Villa, Fulham | 1998 | 2013 |
| Given, ShayShay Given | Ireland | GK | 451 | Blackburn Rovers, Newcastle United, Manchester City, Aston Villa, Stoke City | 1996 | 2016 |
| Brad Friedel | United States | GK | 450 | Liverpool, Blackburn Rovers, Aston Villa, Tottenham Hotspur | 1998 | 2013 |
| O'Shea, JohnJohn O'Shea | Ireland | DF | 445 | Manchester United, Sunderland | 2001 | 2017 |
| Davies, KevinKevin Davies | England | FW | 444 | Blackburn Rovers, Southampton, Bolton Wanderers | 1997 | 2012 |
| Čech, PetrPetr Čech | Czech Republic | GK | 443 | Chelsea, Arsenal | 2004 | 2018 |
| Shearer, AlanAlan Shearer | England | FW | 441 | Blackburn Rovers, Newcastle United | 1992 | 2006 |
| Jääskeläinen, JussiJussi Jääskeläinen | Finland | GK | 436 | Bolton Wanderers, West Ham United | 2001 | 2015 |
| Richard Dunne | Ireland | DF | 431 | Everton, Manchester City, Aston Villa, Queens Park Rangers | 1997 | 2015 |
| Southgate, GarethGareth Southgate | England | DF | 426 | Crystal Palace, Aston Villa, Middlesbrough | 1992 | 2006 |
| Sheringham, TeddyTeddy Sheringham | England | FW | 418 | Nottingham Forest, Tottenham Hotspur, Manchester United, Portsmouth, West Ham United | 1992 | 2006 |
| Murphy, DannyDanny Murphy | England | MF | 417 | Liverpool, Charlton Athletic, Tottenham Hotspur, Fulham | 1997 | 2012 |
| Baines, LeightonLeighton Baines | England | DF | 415 | Wigan Athletic, Everton | 2005 | 2019 |
| Cole, AndyAndy Cole | England | FW | 414 | Newcastle United, Manchester United, Blackburn Rovers, Fulham, Manchester City, Portsmouth, Sunderland | 1993 | 2008 |
| Butt, NickyNicky Butt | England | MF | 411 | Manchester United, Newcastle United, Birmingham City | 1992 | 2009 |
| Downing, StewartStewart Downing | England | MF | 408 | Middlesbrough, Aston Villa, Liverpool, West Ham United | 2002 | 2017 |
| Nolan, KevinKevin Nolan | England | MF | 401 | Bolton Wanderers, Newcastle United, West Ham United | 2001 | 2015 |
| Neville, GaryGary Neville | England | DF | 400 | Manchester United | 1994 | 2011 |
| Howard, TimTim Howard | United States | GK | 399 | Manchester United, Everton | 2003 | 2016 |
| Bowyer, LeeLee Bowyer | England | MF | 397 | Leeds United, West Ham United, Newcastle United, Birmingham City | 1996 | 2011 |
| Duff, DamienDamien Duff | Ireland | MF | 392 | Blackburn Rovers, Chelsea, Newcastle United, Fulham | 1997 | 2014 |
| Cole, AshleyAshley Cole | England | DF | 385 | Arsenal, Chelsea | 2000 | 2014 |
| Lennon, AaronAaron Lennon | England | MF | 385 | Leeds United, Tottenham Hotspur, Everton, Burnley | 2003 | 2020 |
| Boateng, GeorgeGeorge Boateng | Netherlands | MF | 384 | Coventry City, Aston Villa, Middlesbrough, Hull City | 1997 | 2010 |
| Parlour, RayRay Parlour | England | MF | 379 | Arsenal, Middlesbrough | 1992 | 2006 |
| Fowler, RobbieRobbie Fowler | England | FW | 379 | Liverpool, Leeds United, Manchester City, Blackburn Rovers | 1993 | 2008 |
| Young, LukeLuke Young | England | DF | 378 | Tottenham Hotspur, Charlton Athletic, Middlesbrough, Aston Villa, Queens Park Rangers | 1998 | 2012 |
| Cole, JoeJoe Cole | England | MF | 378 | West Ham United, Chelsea, Liverpool, Aston Villa | 1999 | 2015 |
| Carr, StephenStephen Carr | Ireland | DF | 377 | Tottenham Hotspur, Newcastle United, Birmingham City | 1993 | 2011 |
| Yorke, DwightDwight Yorke | Trinidad and Tobago | MF | 375 | Aston Villa, Manchester United, Blackburn Rovers, Birmingham City, Sunderland | 1992 | 2009 |
| Robinson, PaulPaul Robinson | England | GK | 375 | Leeds United, Tottenham Hotspur, Blackburn Rovers, Burnley | 1998 | 2017 |
| Martyn, NigelNigel Martyn | England | GK | 372 | Crystal Palace, Leeds United, Everton | 1992 | 2006 |
| Young, AshleyAshley Young | England | DF | 369 | Watford, Aston Villa, Manchester United | 2006 | 2019 |
| Parker, ScottScott Parker | England | MF | 368 | Charlton Athletic, Chelsea, Newcastle United, West Ham United, Tottenham Hotspur, Fulham | 1998 | 2014 |
| Noble, MarkMark Noble | England | MF | 367 | West Ham United | 2005 | 2020 |
| Keane, RoyRoy Keane | Ireland | MF | 366 | Nottingham Forest, Manchester United | 1992 | 2005 |
| Unsworth, DavidDavid Unsworth | England | DF | 364 | Everton, West Ham United, Portsmouth, Sheffield United, Wigan Athletic | 1992 | 2007 |
| Anelka, NicolasNicolas Anelka | France | FW | 364 | Arsenal, Liverpool, Manchester City, Bolton, Chelsea, West Bromwich Albion | 1997 | 2015 |
| Thomas Sørensen | Denmark | GK | 364 | Sunderland, Aston Villa, Stoke City | 1999 | 2014 |
| Jagielka, PhilPhil Jagielka | England | DF | 364 | Sheffield United, Everton | 2006 | 2019 |
| Perry, ChrisChris Perry | England | DF | 363 | Wimbledon, Tottenham Hotspur, Charlton Athletic | 1994 | 2006 |
| Cahill, GaryGary Cahill | England | DF | 362 | Aston Villa, Bolton Wanderers, Chelsea, Crystal Palace | 2006 | 2020 |
| Sinclair, TrevorTrevor Sinclair | England | MF | 361 | Queens Park Rangers, West Ham United, Manchester City | 1993 | 2007 |
| Delap, RoryRory Delap | Ireland | MF | 359 | Derby County, Southampton, Sunderland, Stoke City | 1998 | 2012 |
| Johnson, GlenGlen Johnson | England | DF | 358 | West Ham United, Chelsea, Portsmouth, Liverpool, Stoke City | 2003 | 2018 |
| Ehiogu, UgoUgo Ehiogu | England | DF | 355 | Aston Villa, Middlesbrough | 1992 | 2006 |
| Touré, KoloKolo Touré | Ivory Coast | DF | 353 | Arsenal, Manchester City, Liverpool | 2002 | 2016 |
| Winterburn, NigelNigel Winterburn | England | DF | 352 | Arsenal, West Ham United | 1992 | 2003 |
| Osman, LeonLeon Osman | England | MF | 352 | Everton | 2003 | 2016 |
| Ferdinand, LesLes Ferdinand | England | FW | 351 | Queens Park Rangers, Newcastle United, Tottenham Hotspur, West Ham United, Leicester City, Bolton Wanderers | 1992 | 2004 |
| Watson, SteveSteve Watson | England | DF | 351 | Newcastle United, Aston Villa, Everton, West Bromwich Albion | 1993 | 2006 |
| Fàbregas, CescCesc Fàbregas | Spain | MF | 350 | Arsenal, Chelsea | 2004 | 2019 |
| Keane, RobbieRobbie Keane | Ireland | FW | 349 | Coventry City, Leeds United, Tottenham Hotspur, Liverpool, West Ham, Aston Villa | 1999 | 2012 |
| Foster, BenBen Foster | England | GK | 348 | Watford, Manchester United, Birmingham City, West Bromwich Albion | 2006 | 2020 |
| Konchesky, PaulPaul Konchesky | England | DF | 347 | Charlton Athletic, Tottenham Hotspur, West Ham United, Fulham, Liverpool, Leicester City | 1999 | 2015 |
| Savage, RobbieRobbie Savage | Wales | MF | 346 | Leicester City, Birmingham City, Blackburn Rovers, Derby County | 1997 | 2008 |
| Seaman, DavidDavid Seaman | England | GK | 344 | Arsenal, Manchester City | 1992 | 2004 |
| Barmby, NickNick Barmby | England | MF | 343 | Tottenham Hotspur, Middlesbrough, Everton, Liverpool, Leeds United, Hull City | 1992 | 2010 |
| Sherwood, TimTim Sherwood | England | MF | 341 | Blackburn Rovers, Tottenham Hotspur, Portsmouth | 1992 | 2003 |
| Fletcher, DarrenDarren Fletcher | Scotland | MF | 341 | Manchester United, West Bromwich Albion, Stoke City | 2003 | 2018 |
| Hart, JoeJoe Hart | England | GK | 340 | Manchester City, Birmingham City, West Ham United, Burnley | 2006 | 2018 |
| Malbranque, SteedSteed Malbranque | France | MF | 336 | Fulham, Tottenham Hotspur, Sunderland | 2001 | 2011 |
| Walcott, TheoTheo Walcott | England | FW | 336 | Arsenal, Everton | 2006 | 2020 |
| Cunningham, KennyKenny Cunningham | Ireland | DF | 335 | Wimbledon, Birmingham City | 1994 | 2006 |
| Hreiðarsson, HermannHermann Hreiðarsson | Iceland | DF | 332 | Crystal Palace, Wimbledon, Ipswich Town, Charlton Athletic, Portsmouth | 1997 | 2010 |
| Beattie, JamesJames Beattie | England | FW | 331 | Blackburn Rovers, Southampton, Everton, Stoke City, Blackpool | 1996 | 2011 |
| Henderson, JordanJordan Henderson | England | MF | 330 | Sunderland, Liverpool | 2008 | 2020 |
| Dodd, JasonJason Dodd | England | DF | 329 | Southampton | 1992 | 2004 |
| Irwin, DenisDenis Irwin | Ireland | DF | 328 | Manchester United, Wolverhampton Wanderers | 1992 | 2004 |
| Le Saux, GraemeGraeme Le Saux | England | DF | 327 | Chelsea, Blackburn Rovers, Southampton | 1992 | 2005 |
| Owen, MichaelMichael Owen | England | FW | 326 | Liverpool, Newcastle United, Manchester United, Stoke City | 1997 | 2013 |
| Campbell, KevinKevin Campbell | England | FW | 325 | Arsenal, Nottingham Forest, Everton, West Bromwich Albion | 1992 | 2006 |
| McAllister, GaryGary McAllister | Scotland | MF | 325 | Leeds United, Coventry City, Liverpool | 1992 | 2002 |
| Kelly, GaryGary Kelly | Ireland | DF | 325 | Leeds United | 1993 | 2004 |
| Kilbane, KevinKevin Kilbane | Ireland | MF | 325 | Sunderland, Everton, Wigan Athletic, Hull City | 1999 | 2010 |
| Clichy, GaëlGaël Clichy | France | DF | 325 | Arsenal, Manchester City | 2003 | 2017 |
| Taylor, MatthewMatthew Taylor | England | MF | 325 | Portsmouth, Bolton Wanderers, West Ham United, Burnley | 2003 | 2015 |
| Valencia, AntonioAntonio Valencia | Ecuador | DF | 325 | Wigan Athletic, Manchester United | 2006 | 2019 |
| Keown, MartinMartin Keown | England | DF | 323 | Everton, Arsenal | 1992 | 2004 |
| Huth, RobertRobert Huth | Germany | DF | 322 | Chelsea, Middlesbrough, Stoke City, Leicester City | 2002 | 2017 |
| Agbonlahor, GabrielGabriel Agbonlahor | England | FW | 322 | Aston Villa | 2006 | 2016 |
| Gallas, WilliamWilliam Gallas | France | DF | 321 | Chelsea, Arsenal, Tottenham Hotspur | 2001 | 2013 |
| Riise, John ArneJohn Arne Riise | Norway | DF | 321 | Liverpool, Fulham | 2001 | 2014 |
| Anderton, DarrenDarren Anderton | England | MF | 319 | Tottenham Hotspur, Birmingham City | 1992 | 2005 |
| Telfer, PaulPaul Telfer | Scotland | DF | 319 | Coventry City, Southampton | 1995 | 2005 |
| Atherton, PeterPeter Atherton | England | DF | 318 | Coventry City, Sheffield Wednesday, Bradford City | 1992 | 2001 |
| Hyypiä, SamiSami Hyypiä | Finland | DF | 318 | Liverpool | 1999 | 2009 |
| Shawcross, RyanRyan Shawcross | England | DF | 317 | Stoke City | 2008 | 2018 |
| Bridge, WayneWayne Bridge | England | DF | 316 | Southampton, Chelsea, Fulham, Manchester City, West Ham United, Sunderland | 1998 | 2012 |
| Wright-Phillips, ShaunShaun Wright-Phillips | England | MF | 316 | Manchester City, Chelsea, Queens Park Rangers | 2000 | 2015 |
| Bergkamp, DennisDennis Bergkamp | Netherlands | FW | 315 | Arsenal | 1995 | 2006 |
| van der Sar, EdwinEdwin van der Sar | Netherlands | GK | 313 | Fulham, Manchester United | 2001 | 2011 |
| Dublin, DionDion Dublin | England | FW | 312 | Manchester United, Coventry City, Aston Villa | 1992 | 2004 |
| Walker, IanIan Walker | England | GK | 312 | Tottenham Hotspur, Leicester City | 1992 | 2004 |
| Morrison, JamesJames Morrison | Scotland | MF | 311 | Middlesbrough, West Bromwich Albion | 2004 | 2017 |
| Schmeichel, PeterPeter Schmeichel | Denmark | GK | 310 | Manchester United, Aston Villa, Manchester City | 1992 | 2003 |
| Brown, WesWes Brown | England | DF | 308 | Manchester United, Sunderland | 1998 | 2016 |
| Vieira, PatrickPatrick Vieira | France | MF | 307 | Arsenal, Manchester City | 1996 | 2011 |
| Ince, PaulPaul Ince | England | MF | 306 | Manchester United, Liverpool, Middlesbrough, Wolverhampton Wanderers | 1992 | 2004 |
| Davis, StevenSteven Davis | Àdàkọ:Country data Northern Ireland Northern Ireland | MF | 306 | Aston Villa, Fulham, Southampton | 2004 | 2018 |
| Long, ShaneShane Long | Ireland | FW | 306 | Reading, West Bromwich Albion, Hull City, Southampton | 2006 | 2020 |
| Dixon, LeeLee Dixon | England | DF | 305 | Arsenal | 1992 | 2002 |
| Wright, AlanAlan Wright | England | DF | 305 | Blackburn Rovers, Aston Villa, Middlesbrough, Sheffield United | 1992 | 2006 |
| Davies, SimonSimon Davies | Wales | MF | 303 | Tottenham Hotspur, Everton, Fulham | 2000 | 2012 |
| Solano, NolbertoNolberto Solano | Peru | MF | 302 | Newcastle United, Aston Villa, West Ham United | 1998 | 2008 |
| Flitcroft, GarryGarry Flitcroft | England | MF | 301 | Manchester City, Blackburn Rovers | 1992 | 2005 |
| McCann, GavinGavin McCann | England | MF | 301 | Everton, Sunderland, Aston Villa, Bolton Wanderers | 1997 | 2010 |
| Zabaleta, PabloPablo Zabaleta | Argentina | DF | 300 | Manchester City, West Ham United | 2008 | 2020 |